Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of Cyclosporine-A

Terreni E, Chetoni P, Tampucci S, Burgalassi S, Al-Kinani AA, Alany RG, Monti D
Pharmaceutics. 2020 Mar 11;12(3):253

In this study a combined strategy based on the association of nanomicelles and mucoadhesive
polymer was investigated to design Assembling Surfactants-Mucoadhesive Polymer Nanomicelles
(ASMP-Nano) with a binary system of two surfactants in combination with hyaluronic acid. The
optimisation of the ASMP-Nano in term of the amount of surfactants, CyA-loading and size
determined the selection of the clear and stable formulation containing 0.105% w/w CyA loaded-
nanomicelles with a size of 14.41 nm. The ASMP-Nano system showed a protective effect towards
epithelial corneal cells with a high cell viability and interacted with cellular barriers favouring the
uptake and the accumulation of CyA into the cells by hindering CyA permeation through
reconstituted corneal epithelial tissue. The ASMP-Nano system represents a optimized
formulation to prolonged the CyA retention time in the precorneal area of the eye.